- Sally Field
- Salma Hayek
- Samuel L. Jackson
- Sandra Bullock
- Sandra Oh
- Santiago Cabrera
- Sara Ramírez
- Sarah Jessica Parker
- Sarah Michelle Gellar
- Sarah Polley
- Sarah Snook
- Scarlett Johansson
- Scott Glenn
- Scott Speedman
- Sean Astin
- Sean Bean
- Sean Connery
- Sean Penn
- Sean Young
- Sendhil Ramamurthy
- Seth Green
- Sharon Stone
- Shia LaBeouf
- Sigourney Weaver
- Simon Baker
- Stanley Tucci
- Stephen Baldwin
- Steve Buscemi
- Sung-Tae Heo
- Susan Sarandon
- Sylvester Stallone